HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoropyridine → N-t-butoxycarbonyl 2-[1-(pyrid-2-yl)piperidin-4-yl]ethylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoropyridine | HCID 9746 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-(Boc-2-aminoethyl)piperidine | HCID 5001226 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | N-t-butoxycarbonyl 2-[1-(pyrid-2-yl)piperidin-4-yl]ethylamine | HCID 22027789 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
To a solution of N-t-butoxycarbonyl 2-(piperidin-2-yl)ethylamine (8.1 g) and DIEA (14.1 mL) in CH3CN (29 mL) is added 2-fluoropyridine (3.5 mL) and the resulting mixture is heated in a sealed-tube at 100° C. for three days. Solvent is removed and the crude product is purified via column chromatography (20% EtOAc/hexane) to afford 3.9 g of N-t-butoxycarbonyl 2-[1-(pyrid-2-yl)piperidin-4-yl]ethylamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07074783B2 |
| Source dataset | uspto-grants-2006_07 |
| ORD ID | ord-c0bdd281f2a1438cbfdc0ec971cfa863 |
| Source note | uspto-grants-2006_07 |