Hydrochloric Acid → HCID 22027811, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-chloro-1,4-dimethyl-benzene (5 g, 35.56 mmol) and chloroacetylchloride (4.0 g, 35.6 mmol) was cooled to 0° C. and treated with aluminum chloride (4.74 g, 35.6 mmol) in small portions. The reaction slurry was diluted with dichloromethane and allowed to warm to room temperature. After 30 min the reaction was poured onto a mixture of ice and 10 mL of concentrated aqueous hydrochloric acid solution. The mixture was extracted with ethyl acetate and the organic layers were combined and washed with saturated aqueous sodium bicarbonate solution. The organic layer was separated, dried (Na2SO4) and concentrated to give approximately 7 g of pure product as a white powder.

Provenance & Evidence