HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1791136Generated: November 4, 2026
4-methylpyrrolidin-2-one → HCID 22027870, compound
https://huagongshe.com/reaction/1791136
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-methylpyrrolidin-2-one | HCID 533920 | — |
| Reactant | N-(3-chlorophenyl)-4-(2-chloropyridin-4-yl)pyrimidin-2-amine | HCID 9905031 | — |
| Reactant | Sodium t-butoxide | HCID 23676156 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Catalyst | Ferrocene-1,1'-bis-(diphenylphosphine) | HCID 635956 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 22027870 | HCID 22027870 | — |
Reaction Steps
In a Schlenk tube (3-chloro-phenyl)-[4-(2-chloro-pyridin-4-yl)-pyrimidin-2-yl]-amine (0.95 g), NaOtBu (0.29 g), dppf (0.1 g), Pd(OAc)2 (0.01 g) and 4-methylpyrrolidin-2one (0.2 g) are added: Three consecutive cycles of vacuum/argon are applied. Thereafter, 10 ml of degassed dioxane is added and the solution is heated to 120° C. (external temperature) for 8 hours. The solvent is removed under vacuum and the crude product is purified over column chromatography (eluent; EE/MeOH=9/1) yielding the title compound, m.p. 162–164° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07074787B2 |
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| Source dataset | uspto-grants-2006_07 |
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| ORD ID | ord-093ba01bce4f43b0bc7ec98e3643815d |
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| Source note | uspto-grants-2006_07 |
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