Alpha-Aminobutyric Acid → 2-(Acetylamino)butanoic acid
Reaction equation
[NH2:1][CH:2]([CH2:6][CH3:7])[C:3]([OH:5])=[O:4].[C:8](OC(=O)C)(=[O:10])[CH3:9]>C(O)(=O)C>[C:8]([NH:1][CH:2]([CH2:6][CH3:7])[C:3]([OH:5])=[O:4])(=[O:10])[CH3:9]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
163 g (1.58 mol) 2-aminobutanoic acid are dissolved in acetic acid, and 242 g (2.37 mol) acetic anhydride are added dropwise. The mixture is stirred for 2 h at 100° C. until completion of reaction, then the solution is evaporated to dryness in vacuo. The solid residue is suspended in ethyl acetate, filtered and washed with diethyl ether.
Workup
- customthe solution is evaporated to dryness in vacuo
- filtrationfiltered
- washwashed with diethyl ether
Sources & evidence
- ORD record
- ord-3775196ad1a841a887da7e8896b6bcf3
- Source dataset
- uspto-grants-2006_07
- Patent number
- US07074790B2
Reaction notes
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