6-(1-aminopropyl)-3-(3-nitrophenyl)-1,2,4-triazin-5(4H)-one → HCID 178457784, compound

HRID 1791185Notes

Reaction equation

HRID 1791185 reaction equation
[NH2:1][CH:2]([C:5]1[C:6](=[O:20])[NH:7][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([N+:17]([O-:19])=[O:18])[CH:12]=2)=[N:9][N:10]=1)[CH2:3][CH3:4].[C:21]([C@@H:25]1[CH2:30][CH2:29][C@H:28]([C:31](Cl)=[O:32])[CH2:27][CH2:26]1)([CH3:24])([CH3:23])[CH3:22]>>[C:21]([C@@H:25]1[CH2:26][CH2:27][C@H:28]([C:31]([NH:1][CH:2]([C:5]2[C:6](=[O:20])[NH:7][C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([N+:17]([O-:19])=[O:18])[CH:12]=3)=[N:9][N:10]=2)[CH2:3][CH3:4])=[O:32])[CH2:29][CH2:30]1)([CH3:24])([CH3:22])[CH3:23]

Participants

3

Reactant 2

HCID 1355941026-(1-aminopropyl)-3-(3-nitrophenyl)-1,2,4-triazin-5(4H)-oneHCID 178445652HCID 178445652, compound

Product 1

HCID 178457784HCID 178457784, compound

Procedure

In analogy to the procedure for Example 16A, 3.2 g (11.6 mmol) 6-(1-aminopropyl)-3-(3-nitrophenyl)-1,2,4-triazin-5(4H)-one (Example 15A), 2.4 g (11.6 mmol) cis-4-tert.-butylcyclohexanecarbonyl chloride (Example 42A) and proportionate amounts of the other reagents are used. The crude product is used in the next step without further purification.

Workup

  1. customThe crude product is used in the next step without further purification

Sources & evidence

ORD record
ord-cfcdddc5545c4ae5a70abee645f7a605
Source dataset
uspto-grants-2006_07
Patent number
US07074790B2

Reaction notes

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