6-(1-Aminopropyl)-3-(4-bromophenyl)-1,2,4-triazin-5(4H)-one → HCID 178437645, compound

HRID 1791189Notes

Reaction equation

HRID 1791189 reaction equation
[NH2:1][CH:2]([C:5]1[C:6](=[O:18])[NH:7][C:8]([C:11]2[CH:16]=[CH:15][C:14]([Br:17])=[CH:13][CH:12]=2)=[N:9][N:10]=1)[CH2:3][CH3:4].[C:19]([C@@H:23]1[CH2:28][CH2:27][C@H:26]([C:29](Cl)=O)[CH2:25][CH2:24]1)([CH3:22])([CH3:21])[CH3:20]>>[Br:17][C:14]1[CH:15]=[CH:16][C:11]([C:8]2[NH:7][C:6](=[O:18])[C:5]3=[C:2]([CH2:3][CH3:4])[N:1]=[C:29]([C@H:26]4[CH2:27][CH2:28][C@@H:23]([C:19]([CH3:20])([CH3:22])[CH3:21])[CH2:24][CH2:25]4)[N:10]3[N:9]=2)=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 1355940826-(1-Aminopropyl)-3-(4-bromophenyl)-1,2,4-triazin-5(4H)-oneHCID 178445652HCID 178445652, compound

Product 1

HCID 178437645HCID 178437645, compound

Procedure

In analogy to the procedure for Example 23A, 7.6 g (24.6 mmol) 6-(1-aminopropyl)-3-(4-bromophenyl)-1,2,4-triazin-5(4H)-one (Example 29A), 4.98 g (24.55 mmol) cis-4-tert-butylcyclohexylcarbonyl chloride (Example 42A) and proportionate amounts of the other reagents are used.

Sources & evidence

ORD record
ord-93fdfe881a7d4298bc877d00cd996986
Source dataset
uspto-grants-2006_07
Patent number
US07074790B2

Reaction notes

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