HCID 59015781, compound → HCID 59015784, compound

HRID 1791201Notes

Reaction equation

HRID 1791201 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[C:17]([F:20])([F:19])[F:18])=[CH:7][C:6]=1[N+:21]([O-])=O)=[O:4].[H][H]>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[C:17]([F:18])([F:19])[F:20])=[CH:7][C:6]=1[NH2:21])=[O:4]

Participants

4

Reactant 2

HCID 59015781HCID 59015781, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 59015784HCID 59015784, compound

Reagents, catalysts & solvents 1

HCID 178418397HCID 178418397, compoundCatalyst

Procedure

In a Parr apparatus, hydrogenate an ethanolic solution of 3-nitro-2′-trifluoromethyl-biphenyl-4-carboxylic acid methyl ester (5.54 g, 0.0169 mol) under 55 psi of hydrogen using tetrakis(triphenylphosphine)palladium(0) (300 mg). After 18 hours, filter the mixture through celite and concentrate under reduced pressure to give 3-amino-2′-trifluoromethyl-biphenyl-4-carboxylic acid methyl ester as a solid.

Workup

  1. filtrationfilter the mixture through celite
  2. concentrationconcentrate under reduced pressure

Sources & evidence

ORD record
ord-e3b36a21bf3042018d6e832c2ae48db7
Source dataset
uspto-grants-2006_07
Patent number
US07074799B2

Reaction notes

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