反应详情

温度

115 °C

To a solution of 7-bromo-3H-quinazolin-4-one (100 mg, 0.444 mmol) in toluene/dioxane (3:1), add 2-tributylstannanyl-pyridine (162 mg, 0.444 mmol) followed by tetrakis-(triphenylphosphine)-palladium(0) (26 mg, 0.022 mmol). Bubble dry nitrogen through the solution for 10 minutes then heat the stirring solution to 115° C. under a nitrogen atmosphere. After several minutes the reaction mixture becomes homogeneous. After 16 hours, cool the reaction vessel and collect the precipitate via filtration. Wash the solid with 25% EtOAc/hexanes followed by hexanes to give 7-pyridin-2-yl-3H-quinazolin-4-one as a beige solid.

1. customBubble dry nitrogen through the solution for 10 minutes
2. waitAfter several minutes the reaction mixture becomes homogeneous
3. temperaturecool the reaction vessel
4. customcollect the precipitate
5. filtrationvia filtration
6. washWash the solid with 25% EtOAc/hexanes