HRID1791226

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(=O)Nc1cc(-c2ncccc2C(F)(F)F)ccc1C(N)=O

HCID22030471

未命名化合物

PRODUCTS

生成物

结构：Cc1nc(O)c2ccc(-c3ncccc3C(F)(F)F)cc2n1

HCID178433407

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID14798

Sodium Hydroxide

HNaO

PROCEDURE

实验过程

Suspend 2-acetylamino-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide in 20 ml of 20% NaOH, stir for 30 minutes at room temperature. Filter, acidify to pH=6, extract with EtOAc, and concentrate under vacuum to give 2-methyl-7-(3-trifluoromethyl-pyridin-2-yl)-quinazolin-4-ol.

WORKUP

后处理

filtrationFilter
extractionextract with EtOAc
concentrationconcentrate under vacuum