HCID 86592617, compound → HCID 22030324, compound

HRID 1791232Notes

Reaction equation

[ClH:1].[C:2]([C:6]1[CH:11]=[CH:10][C:9]([N-:12][C:13]2[C:22]3[C:17](=[CH:18][C:19]([C:23]4[C:28]([C:29]([F:32])([F:31])[F:30])=[CH:27][CH:26]=[CH:25][N:24]=4)=[CH:20][CH:21]=3)[N:16]=[CH:15][N:14]=2)=[CH:8][CH:7]=1)([CH3:5])([CH3:4])[CH3:3].FC(F)(F)C1C(C2C=C3C(C(O)=NC=N3)=CC=2)=NC=CC=1>>[ClH:1].[C:2]([C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13]2[C:22]3[C:17](=[CH:18][C:19]([C:23]4[C:28]([C:29]([F:31])([F:30])[F:32])=[CH:27][CH:26]=[CH:25][N:24]=4)=[CH:20][CH:21]=3)[N:16]=[CH:15][N:14]=2)=[CH:8][CH:7]=1)([CH3:5])([CH3:3])[CH3:4]

Participants

Reactant 2

HCID 86592617HCID 86592617, compound

HCID 178517950HCID 178517950, compound

Product 1

HCID 22030324HCID 22030324, compound

Procedure

Using procedures analogous to those described above (see, for example, Schemes 1 and 2), (4-tert-Butyl-phenyl)-[7-(3-trifluoromethyl-pyridin-2-yl)-quinazolin-4-yl]-amide hydrochloride is prepared from 7-(3-trifluoromethyl-pyridin-2-yl)-quinazolin-4-ol in two steps. Mass spec. 422.2.

Sources & evidence

ORD record: ord-f2e2eccf6d8f41b5a9eb8ad2f9b6aa0c
Source dataset: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07074799B2

Reaction notes

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