Acetic Anhydride → HCID 10004528, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 3-(5-fluoro-2-methoxy-phenyl)-3-methyl-1-quinolin-4-ylmethyl-1-trifluoromethyl-butylamine (42.0 mg, 0.1 mmol) in dichloroethane (4 mL) was treated with acetic anhydride (71 μL, 1.0 mmol). The mixture was stirred for 16 h at 85° C. and quenched with NaHCO3 (sat, 4 mL). Phases were separated and the aqueous layer was extracted with CHCl3 (3×2 mL). The combined organic layers were dried over MgSO4, filtered and concentrated in vacuo. The residue was purified on SiO2 (50%–70%, EtOAc:hexanes) to give 34.0 mg (74%) of the title product.

Provenance & Evidence