Tetrahydrofuran → HCID 9969252, compound

Participants

Reaction Steps

The product from Step 3 of Example 45 was dissolved in 0.5 ml anhydrous THF and 50 μL (COCl)2 was added. The solution was mixed at room temperature overnight with orbital shaking. An aliquot removed for LC analysis indicated that the reaction was complete. The solution was added to 1 mL aqueous NaHCO3 and the vial was capped and shaken. 0.1 mL 2N HCl was added and the vial was again capped and shaken. The reaction was concentrated to dryness under vacuum. The residue was purified by RP-HPLC (see Note 1 below) to give 6.4 mg of the title compound as an oil.

Provenance & Evidence