反应详情

Under nitrogen, to a solution of 2,3-dimethyl-5-hydroxyindole (643 mg, 4 mmol), in DMF (10 ml) was added potassium carbonate (690 mg, 5 mmol). After stirring for 15 minutes at ambient temperature, 7-benzyloxy-4-chloro-6-methoxyquinazoline (1 g, 3.33 mmol), (prepared as described for the starting material in Example 1), was added. The mixture was heated at 90° C. for 2 hours followed by 30 minutes at 95° C. After cooling, the mixture was poured onto water (100 ml) cooled at 5° C. The precipitate was filtered, washed with water, followed by ether and dried under vacuum to give 7-benzyloxy-4-(2,3-dimethylindol-5-yloxy)-6-methoxyquinazoline (1.4 g, 95%).

1. additionwas added
2. temperatureThe mixture was heated at 90° C. for 2 hours
3. waitfollowed by 30 minutes at 95° C
4. temperatureAfter cooling
5. additionthe mixture was poured onto water (100 ml)
6. temperaturecooled at 5° C
7. filtrationThe precipitate was filtered
8. washwashed with water
9. customdried under vacuum