Diethylene Glycol Monomethyl Ether → HCID 22030570, compound

HRID 1791626Notes

Reaction equation

HRID 1791626 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([O:12][C:13]3[CH:14]=[C:15]4[C:19](=[CH:20][CH:21]=3)[NH:18][CH:17]=[CH:16]4)=[N:7][CH:8]=[N:9]2)=[CH:4][C:3]=1[O:22][CH3:23].[CH3:24][O:25][CH2:26][CH2:27][O:28][CH2:29][CH2:30]O>>[NH:18]1[C:19]2[C:15](=[CH:14][C:13]([O:12][C:6]3[C:5]4[C:10](=[CH:11][C:2]([O:1][CH2:30][CH2:29][O:28][CH2:27][CH2:26][O:25][CH3:24])=[C:3]([O:22][CH3:23])[CH:4]=4)[N:9]=[CH:8][N:7]=3)=[CH:21][CH:20]=2)[CH:16]=[CH:17]1

Participants

3

Reactant 2

HCID 8134Diethylene Glycol Monomethyl EtherHCID 1357631167-hydroxy-4-(1H-indol-5-yloxy)-6-methoxyquinazoline

Product 1

HCID 22030570HCID 22030570, compoundYield 42.2%

Procedure

Using an analogous procedure to that described in Example 91, 7-hydroxy-4-(indol-5-yloxy)-6-methoxyquinazoline (89 mg) was reacted with 2-(2-methoxyethoxy)ethanol (70 mg) to give 4-(indol-5yloxy)-6-methoxy-7-(2-(2-methoxyethoxy)ethoxy)quinazoline (50 mg, 42%).

Sources & evidence

ORD record
ord-7c482d15c6cb4a9c8b8c79fb205a2341
Source dataset
uspto-grants-2006_07
Patent number
US07074800B1

Reaction notes

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