HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1791735Generated: November 3, 2026
Sodium Hydroxide → 3-((Pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one
https://huagongshe.com/reaction/1791735
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 6-Methoxy-7-((piperidin-4-yl)methoxy)-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one hydrochloride | HCID 22030672 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-((Pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one | HCID 20689173 | 132.6% |
Reaction Steps
To a suspension of 6-methoxy-7-(piperidin-4-ylmethoxy)-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one hydrochloride (34 g, 84 mmol), (prepared as described for the starting material in Example 12), in water cooled at 0° C. was added 1N sodium hydroxide until the mixture was at pH8. The solution was extracted with trichloromethane and the organic layer was dried (MgSO4), filtered and evaporated to give 6-methoxy-7-piperidin-4-ylmethoxy)-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one (29 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07074800B1 |
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| Source dataset | uspto-grants-2006_07 |
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| ORD ID | ord-1fedcee2041d4060b14263b35a021e3b |
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| Source note | uspto-grants-2006_07 |
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