Dichloromethane → HCID 22030751, compound

HRID 1791739Notes

Reaction equation

HRID 1791739 reaction equation
[C:1]([CH2:4][C:5]1[C:6]([F:15])=[C:7]([F:14])[CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])(=[O:3])[CH3:2].O.[O-2].[O-2].[O-2].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.[Al+3].[Al+3].[CH:34](OC)(OC)[O:35]C.[CH2:41](Cl)Cl>>[F:14][C:7]1[CH:8]=[CH:9][C:10]([N+:11]([O-:13])=[O:12])=[C:5]([CH2:4][C:1]([O:35][CH3:34])([O:3][CH3:41])[CH3:2])[C:6]=1[F:15]

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 9005Trimethyl orthoformateHCID 142688761-(2,3-Difluoro-6-nitrophenyl)propan-2-oneHCID 71586775Bentonite

Product 1

HCID 22030751HCID 22030751, compoundYield 88%

Procedure

A solution of 3-acetylmethyl-1,2-difluoro-4-nitrobenzene (500 mg, 2.3 mmol) in methylene chloride (5 ml) containing montmorillonite K10 (1 g) and trimethyl orthoformate (5 ml) was stirred for 24 hours at ambient temperature. The solid was filtered, washed with methylene chloride and the filtrate was evaporated to give 1,2-difluoro-3-(2,2dimethoxypropyl)-4-nitrobenzene (534 mg, 88%).

Workup

  1. filtrationThe solid was filtered
  2. washwashed with methylene chloride
  3. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-e34a6514760e4fefa10d12665cc4f0f4
Source dataset
uspto-grants-2006_07
Patent number
US07074800B1

Reaction notes

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