反应详情

A solution of 3-acetylmethyl-1,2-difluoro-4-nitrobenzene (500 mg, 2.3 mmol) in methylene chloride (5 ml) containing montmorillonite K10 (1 g) and trimethyl orthoformate (5 ml) was stirred for 24 hours at ambient temperature. The solid was filtered, washed with methylene chloride and the filtrate was evaporated to give 1,2-difluoro-3-(2,2dimethoxypropyl)-4-nitrobenzene (534 mg, 88%).

1. filtrationThe solid was filtered
2. washwashed with methylene chloride
3. customthe filtrate was evaporated