反应详情

Benzenesulfonyl chloride (0.24 mL; 1.9 mmol) was added to a stirred solution of amino-3-[2-(4-cyanophenyl)ethoxy]-2-methylbenzene (0.42 g ; 1.7 mmol; from step (iii) above) in dry pyridine (20 mL) under nitrogen. The reaction was left overnight at room temperature. After evaporation of the solvent the residue was partitioned between 10% aqueous HCl and EtOAc. The organic layer was washed with brine, dried (MgSO4) and the solvent removed in vacuo. Purification by flash chromatography afforded 0.47 g (72%) of the sub-title compound.

1. customAfter evaporation of the solvent the residue
2. customwas partitioned between 10% aqueous HCl and EtOAc
3. washThe organic layer was washed with brine
4. dry with materialdried (MgSO4)
5. customthe solvent removed in vacuo
6. customPurification by flash chromatography