Phenyl isocyanate → HCID 22033724, compound

Participants

Reaction Steps

A mixture of 2-propionylamino-5-(2-amino-phenoxy)-benzoic acid methyl ester (50.0 mg, 0.153 mmol, prepared as described in EXAMPLE 2) and phenyl isocyanate (21.0 mg, 0.175 mmol) in CH2Cl2 (10 mL) was stirred at room temperature for 2 hours. The solvent was removed by evaporation and the crude ester product was hydrolysed in methanol (1 mL) and 1M NaOH (1 mL) over night. The reaction mixture was acidified with 1M HCl and the product was collected by filtration (54 mg, total yield 80%).

Provenance & Evidence