1,4-Dioxane hydrochloride → HCID 67507136, compound

HRID 1791892Notes

Reaction equation

HRID 1791892 reaction equation
[NH2:1][C@@H:2]1[CH2:6][N:5](C(OC(C)(C)C)=O)[C@H:4]([C:14]([N:16]2[CH2:20][CH2:19][CH2:18][C@H:17]2[C:21]#[N:22])=[O:15])[CH2:3]1.[ClH:23].O1CCOCC1>>[ClH:23].[ClH:23].[NH2:1][C@@H:2]1[CH2:6][NH:5][C@H:4]([C:14]([N:16]2[CH2:20][CH2:19][CH2:18][C@H:17]2[C:21]#[N:22])=[O:15])[CH2:3]1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 67507416HCID 67507416, compound

Product 1

HCID 67507136HCID 67507136, compound

Procedure

(S)-1-((2S,4S)-4-Amino-1-tert-butoxycarbonyl-2-pyrrolidinylcarbonyl)-2-cyanopyrrolidine (title compound of Reference Example 3, 308 mg) was dissolved in 4 mol/L hydrochloric acid-1,4-dioxane (1.25 mL), and the mixture was stirred at room temperature for 27 hr. The solvent was evaporated under reduced pressure and tetrahydrofuran was added thereto. The precipitated solid was collected by filtration to give the title compound (214 mg).

Sources & evidence

ORD record
ord-27ee47580eff4093893eb1a7d0d256ad
Source dataset
uspto-grants-2006_07
Patent number
US07074794B2

Reaction notes

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