HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1791945Generated: October 25, 2026
Diethanolamine → 4-[N,N-bis(2-hydroxyethyl)amino]-2-trifluoromethylquinoline
https://huagongshe.com/reaction/1791945
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethanolamine | HCID 8113 | — |
| Reactant | 4-Chloro-2-(trifluoromethyl)quinoline | HCID 2736709 | — |
| Solvent | Sodium chloride; water | HCID 57417360 | — |
| Product | 4-[N,N-bis(2-hydroxyethyl)amino]-2-trifluoromethylquinoline | HCID 22028887 | — |
Reaction Steps
Diethanolamine (20 mL) was added to 4-chloro-2-trifluoromethylquinoline (5.04 g), and the mixture was stirred at 80° C. for 19 hr. Brine was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was dried and concentrated under reduced pressure. The residue was purified by silica gel chromatography to give 4-[N,N-bis(2-hydroxyethyl)amino]-2-trifluoromethylquinoline (3.40 g) as a white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07074794B2 |
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| Source dataset | uspto-grants-2006_07 |
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| ORD ID | ord-4ef913eea72040918018fad2ac95998a |
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| Source note | uspto-grants-2006_07 |
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