HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1791949Generated: October 31, 2026
Piperazine → 7-Chloro-4-(piperazin-1-yl)quinoline
https://huagongshe.com/reaction/1791949
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 4,7-Dichloroquinoline | HCID 6866 | — |
| Solvent | Water | HCID 962 | — |
| Product | 7-Chloro-4-(piperazin-1-yl)quinoline | HCID 738389 | 41.1% |
Reaction Steps
Piperazine (65.2 g) was melted by heating at 120° C., and 4,7-dichloroquinoline (15.0 g) was added thereto. The mixture was stirred at 120° C. for 2.5 hr and the reaction mixture was added to water. The mixture was extracted with chloroform and concentrated under reduced pressure to give 1-(7-chloro-4-quinolyl)piperazine (7.72 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07074794B2 |
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| Source dataset | uspto-grants-2006_07 |
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| ORD ID | ord-816c337a791d4fc79493c67e92e65e50 |
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| Source note | uspto-grants-2006_07 |
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