HCID 11779701, compound → HCID 69462298, compound

Participants

Reaction Steps

Anhydrous ethanol (1.0 ml) was added to a mixture of the title compound and its diastereomer, (2S)-2-[1-(diethoxymethyl)cyclopropyl]-2-{[(1S)-1-phenylethyl]amino}acetonitrile (the mixture: 16 mg, mixing ratio=1:1.8, (2S)-2-[1-(diethoxymethyl)cyclopropyl]-2-{[(1S)-1-phenylethyl]amino}acetonitrile was a main component). After stirring at 60° C. for 30 minutes in an argon gas stream, the reaction mixture was concentrated under reduced pressure. The diastereomer mixing ratio of the reuslting colorless crystals (16 mg) was found to be 3.4:1 based on the integral ratio of 1H-NMR ((2S)-2-[1-(diethoxymethyl)cyclopropyl]-2-{[(1S)-1-phenylethyl]amino}acetonitrile was a main component).

Provenance & Evidence