HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-Chlorotheophylline → HCID 23081921, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-Chlorotheophylline | HCID 10661 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 23081921 | HCID 23081921 | 61.4% |
Reaction Conditions
| Temperature | 110 °C |
|---|
Reaction Steps
8-Chlorotheophylline (3.5 g) and piperazine-1-carboxylic acid tert-butyl ester (11.69 g) were mixed, and stirred at 110° C. overnight. Then, the reaction mixture was diluted with ethyl acetate and water, insoluble white solid was collected by filtration, and washed with ethyl acetate to give 3.65 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07074798B2 |
| Source dataset | uspto-grants-2006_07 |
| ORD ID | ord-480476da2ef24e60b6fbd0355d35cc33 |
| Source note | uspto-grants-2006_07 |