tert-Butyl piperazine-1-carboxylate → HCID 23081901, compound

Participants

Reaction Conditions

Reaction Steps

8-Chloro-7-(2-chlorophenyl)-3-methyl-3,7-dihydropurine-2,6-dione (58 mg) and 1-(tert-butoxycarbonyl)piperazine (150 mg) were mixed. The reaction solution was stirred at 150° C. for 4 hours, then diluted with ethyl acetate, and washed with water. The organic layer was dried over anhydrous magnesium sulfate, filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography to obtain 44 mg of the title compound from a fraction eluted with ethyl acetate.

Provenance & Evidence