Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Chloromethyl pivalate | HCID 87885 | — |
| Reactant | 7-Benzyl-1H-purine-2,6(3H,7H)-dione | HCID 12500507 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 15332397 | HCID 15332397 | — |
Reaction Steps
7-Benzylxanthine (9.54 g) was dissolved in N,N-dimethylformamide (250 ml), and potassium carbonate (17 g) and chloromethyl pivalate (14.2 ml) were added thereto. The reaction solution was stirred at 50° C. overnight, then diluted with ethyl acetate, and washed with water and 1 N hydrochloric acid. The organic layer was dried over anhydrous magnesium sulfate, filtered, and the solvent was removed by distillation. The residue was purified by silica gel chromatography to obtain 12.8 g of the title compound from a fraction eluted with hexane-ethyl acetate (3:2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07074798B2 |
|---|
| Source dataset | uspto-grants-2006_07 |
|---|
| ORD ID | ord-b65da21e126f4f65b15f36373117b212 |
|---|
| Source note | uspto-grants-2006_07 |
|---|
