TBAF tetrahydrofuran → HCID 86760146, compound

Participants

Reaction Steps

1α,3β-Bis(tert-butyldimethylsilyloxy)-20-{4-triethylsilyloxy-4-methyl-(2Z)-pentenyloxy}-20-methylpregna-5,7,16-triene (140 mg, 0.178 mmol) and a 1M tetra-n-butylammonium fluoride tetrahydrofuran solution (5 ml) were subjected to reaction using a procedure similar to that of Example 5(2) (4 hours), worked up and purified by column chromatography (ethyl acetate) to give the titled compound (63 mg, 80%) as a colorless foam.

Provenance & Evidence