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HRID1792192

反应详情

EQUATION

反应方程式

HRID 1792192 的结构方程式

REACTANTS

反应物

4
结构：[H-].[Na+]
HCID24758

Sodium hydride

HNa

结构：C1COCCOCCOCCOCCO1
HCID36336

1,4,7,10,13-Pentaoxacyclopentadecane

C10H20O5

结构：CCC(CC)(C/C=C/Br)O[Si](CC)(CC)CC
HCID22027621

未命名化合物

结构：CC(C)(O)C1=CC[C@H]2C3=CC=C4C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)[C@]4(C)[C@H]3CC[C@]12C
HCID69629925

未命名化合物

PRODUCTS

生成物

1
结构：CCC(CC)(C/C=C/OC(C)(C)C1=CC[C@H]2C3=CC=C4C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)[C@]4(C)[C@H]3CC[C@]12C)O[Si](CC)(CC)CC
HCID86760151

未命名化合物

收率 62%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

1α,3β-Bis(tert-butyldimethylsilyloxy)-20-hydroxy-20-methylpregna-5,7,16-triene (400 mg, 0.698 mmol), 1-bromo-4-ethyl-4-triethylsilyloxy-(2E)-hexene (0.897 g, 2.79 mmol), sodium hydride (60% in oil, 0.168 g, 4.188 mmol), 15-crown-5 (0.14 ml, 0.698 mmol) and tetrahydrofuran (12 ml) were subjected to reaction using a procedure similar to that of Example 5(1) (3 hours), worked up and purified by column chromatography (hexane:toluene=2:1) to give the titled compound (0.35 g, 62%) as a yellow foam.

WORKUP

后处理

  1. customof Example 5(1) (3 hours)
  2. custompurified by column chromatography (hexane:toluene=2:1)