Quinoline → 17-{4-ethyl-4-hydroxy-(2Z)-hexenyloxymethyl}-1alpha,3beta-dihydroxyandrosta-5,7,16-triene

Participants

Reaction Steps

The fraction (0.3 g) containing 17-(4-ethyl-4-hydroxy-2-hexynyloxymethyl)-1α,3β-dihydroxyandrosta-5,7,16-triene obtained in Example 11 (2), 5% palladium/barium sulfate (0.3 g), quinoline (0.03 ml, 0.2538 mmol) and methanol (6.8 ml) were subjected to reaction using a procedure similar to that of Example 29(1) (4 hours) and worked up to give a mixture (0.80 mg) containing the targeted compound.

Provenance & Evidence