HRID1792214

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C1CCOC1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]

HCID11078149

未命名化合物

结构：CCC(CC)(CCCSCC1=CC[C@H]2C3=CC=C4C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)[C@]4(C)[C@H]3CC[C@]12C)O[Si](CC)(CC)CC

HCID69630434

未命名化合物

PRODUCTS

生成物

结构：CCC(O)(CC)CCCSCC1=CC[C@H]2C3=CC=C4C[C@@H](O)C[C@H](O)[C@]4(C)[C@H]3CC[C@]12C

HCID69630775

未命名化合物

收率 77%

PROCEDURE

实验过程

1α,3β-Bis(tert-butyldimethylsilyloxy)-17-{4-ethyl-4-(triethylsilyloxy)hexylthiomethyl}androsta-5,7,16-triene (310 mg, 0.386 mmol) and a 1M tetra-n-butylammonium fluoride tetrahydrofuran solution (5 ml) were subjected to reaction using a procedure similar to that of Example 5(2) (3 hours), worked up and purified by column chromatography (ethyl acetate) to give the titled compound (136 mg, 77%) as a colorless foam.

WORKUP

后处理

customof Example 5(2) (3 hours)
custompurified by column chromatography (ethyl acetate)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4c7ecfbff1d6454585daf4f49aec49d8
来源数据集: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07074777B2
来源说明: uspto-grants-2006_07

反应 SMILES

[Si]([O:8][C@@H:9]1[C@@:26]2([CH3:27])[C:13](=[CH:14][CH:15]=[C:16]3[C@@H:25]2[CH2:24][CH2:23][C@@:21]2([CH3:22])[C@H:17]3[CH2:18][CH:19]=[C:20]2[CH2:28][S:29][CH2:30][CH2:31][CH2:32][C:33]([CH2:44][CH3:45])([O:36][Si](CC)(CC)CC)[CH2:34][CH3:35])[CH2:12][C@@H:11]([O:46][Si](C(C)(C)C)(C)C)[CH2:10]1)(C(C)(C)C)(C)C.O1CCCC1.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>>[CH2:34]([C:33]([OH:36])([CH2:44][CH3:45])[CH2:32][CH2:31][CH2:30][S:29][CH2:28][C:20]1[C@:21]2([CH2:23][CH2:24][C@H:25]3[C:16](=[CH:15][CH:14]=[C:13]4[C@:26]3([CH3:27])[C@@H:9]([OH:8])[CH2:10][C@H:11]([OH:46])[CH2:12]4)[C@@H:17]2[CH2:18][CH:19]=1)[CH3:22])[CH3:35]