HCID 86760158, compound → HCID 69630335, compound

Participants

Reaction Conditions

Reaction Steps

To 1α,3β-bis(tert-butyldimethylsilyloxy)-17β-(hydroxymethyl)androsta-5,7-diene 4-phenyl-1,2,4-triazoline-3,5-dione adduct (6.3 g), was added 1,3-dimethyl-2-imidazolidinone (100 ml), followed by heating at 140° C. for 3 hours. The reaction mixture was extracted with hexane, the organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate and evaporated under reduced pressure to remove the solvent. The thus obtained residue was purified by column chromatography (hexane:ethyl acetate=5:1) to give the titled compound (3.61 g).

Provenance & Evidence