4-[9-(4-Cyanobutylthio)nonyl]-7-methoxy-3-(4-methoxyphenyl)-3-methylthiochroman → (3RS,4RS)-4-[9-(4-cyanobutylthio)nonyl]-7-hydroxy-3-(4-hydroxyphenyl)-3-methylthiochroman

HRID 1792392Notes

Reaction equation

HRID 1792392 reaction equation
[C:1]([CH2:3][CH2:4][CH2:5][CH2:6][S:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH:17]1[C:26]2[C:21](=[CH:22][C:23]([O:27]C)=[CH:24][CH:25]=2)[S:20][CH2:19][C:18]1([C:30]1[CH:35]=[CH:34][C:33]([O:36]C)=[CH:32][CH:31]=1)[CH3:29])#[N:2].OC1C=C2C(C(CCCCCCCCCSCCCC(F)(F)C(F)(F)F)C(C3C=CC(O)=CC=3)(C)CS2)=CC=1>>[C:1]([CH2:3][CH2:4][CH2:5][CH2:6][S:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH:17]1[C:26]2[C:21](=[CH:22][C:23]([OH:27])=[CH:24][CH:25]=2)[S:20][CH2:19][C:18]1([C:30]1[CH:35]=[CH:34][C:33]([OH:36])=[CH:32][CH:31]=1)[CH3:29])#[N:2]

Participants

3

Reactant 2

HCID 220330614-[9-(4-Cyanobutylthio)nonyl]-7-methoxy-3-(4-methoxyphenyl)-3-methylthiochromanHCID 22033340(3RS,4RS)-7-hydroxy-3-(4-hydroxyphenyl)-3-methyl-4-[9-(4,4,5,5,5-pentafluoropentylthio)nonyl]thiochroman

Product 1

HCID 22033367(3RS,4RS)-4-[9-(4-cyanobutylthio)nonyl]-7-hydroxy-3-(4-hydroxyphenyl)-3-methylthiochroman

Procedure

The title compound was prepared from 4-[9-(4-cyanobutylthio)nonyl]-7-methoxy-3-(4-methoxyphenyl)-3-methylthiochroman according to the same method for the synthesis of (3RS,4RS)-7-hydroxy-3-(4-hydroxyphenyl)-3-methyl-4-[9-(4,4,5,5,5-pentafluoropentylthio)nonyl]thiochroman described in International Patent Appln. No. PCT/KR97/00265.

Sources & evidence

ORD record
ord-ed6dc82dc74744d98d88e5069ca0df98
Source dataset
uspto-grants-2006_07
Patent number
US07074819B2

Reaction notes

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