HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 6-Bromo-3-iodoimidazo(1,2-a)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Thiosulfate | HCID 24477 | — |
| Reactant | N-Iodosuccinimide | HCID 120273 | — |
| Reactant | 6-Bromoimidazo[1,2-a]pyridine | HCID 2795547 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-Bromo-3-iodoimidazo(1,2-a)pyridine | HCID 22031632 | 91.5% |
Reaction Steps
10.7 g N-iodosuccinimide was added in divided portions to 100 mL solution of 9 g 6-bromoimidazo[1,2-a]pyridine in N,N-dimethylformamide, and the mixture was stirred for 2 hours. An aqueous sodium thiosulfate solution was added thereto and stirred for 1 hour, water was added thereto, and the formed crystals were collected by filtration. The product was recrystallized from tetrahydrofuran/ethanol to give 13.5 g of the title compound (colorless crystals).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07074801B1 |
| Source dataset | uspto-grants-2006_07 |
| ORD ID | ord-91676370c4b44065a709dbf40d068486 |
| Source note | uspto-grants-2006_07 |