HCID 22031430, compound → HCID 22031908, compound

HRID 1792432Notes

Reaction equation

HRID 1792432 reaction equation
C(OC[N:9]1[C:13]2[CH:14]=[C:15]([Br:18])[CH:16]=[CH:17][C:12]=2[N:11]=[C:10]1[S:19][CH2:20][CH3:21])(=O)C(C)(C)C.C(OCN1C2C=CC(Br)=CC=2N=C1SCC)(=O)C(C)(C)C>>[Br:18][C:15]1[CH:16]=[CH:17][C:12]2[N:11]=[C:10]([S:19][CH2:20][CH3:21])[NH:9][C:13]=2[CH:14]=1

Participants

3

Reactant 2

HCID 22031430HCID 22031430, compoundHCID 22032361HCID 22032361, compound

Product 1

HCID 22031908HCID 22031908, compound

Procedure

11.8 g mixture of [6-bromo-2-(ethylsulfanyl)-1H-benzo[d]imidazol-1-yl]methyl pivalate and [5-bromo-2-(ethylsulfanyl)-1H-benzo[d]imidazol-1-yl]methyl pivalate in a ratio of 1:1 was obtained as pale yellow solid by the same method as in Production Example 64 from 8.1 g 6-bromo-2-(ethylsulfanyl)-1H-benzo[d]imidazole obtained in Production Example 72. 7.2 g of the title compound was obtained as a colorless amorphous by the same method as in Production Example 65 from 6.9 g of the above product and 10 g 3-(4-fluorophenyl)-1-trityl-1H-4-pyrazolylboronic acid (compound in Production Example 25).

Sources & evidence

ORD record
ord-6487d75bc2b74dfa990fbea3b98399e4
Source dataset
uspto-grants-2006_07
Patent number
US07074801B1

Reaction notes

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