Water → HCID 23537236, compound

Participants

Reaction Steps

0.33 mL trifluoroacetic anhydride was added to a solution of 556 mg of (4S)-4-hydroxy-4-(6-iodo-1,3-benzothiazol-2-yl)butane amide obtained in Production Example 299 and 0.25 mL pyridine in tetrahydrofuran under ice-cooling, and the mixture was stirred for 2 hours. Water was added thereto, the reaction solution was then extracted with ethyl acetate, and the organic layer was dried over magnesium sulfate and purified by NH silica gel chromatography. The product was recrystallized from ethanol/ethyl acetate/hexane, to give 390 mg of the title compound as colorless crystals.

Provenance & Evidence