4-Iodobenzenesulfonyl chloride → HCID 22031478, compound

Participants

Reaction Steps

760 mg of N1-(4-methyl-1,3-thiazol-2-yl)-4-iodo-1-benzene sulfonamide obtained by reacting 4-iodobenzenesulfonyl chloride with 2-amino-4-methylthiazole in pyridine was dissolved in a solvent mixture of 5 mL methanol and 3 mL tetrahydrofuran, then 1.1 mL (trimethylsilyl)diazomethane (2 M hexane solution) was added thereto, and the mixture was stirred for 1 hour. The solvent was evaporated and purified with an NH silica gel column, to give 335 mg of the title compound as a pale yellow solid.

Provenance & Evidence