Benzenamine, 3-(methylthio)- → HCID 9072559, compound

HRID 1792476Notes

Reaction equation

HRID 1792476 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([F:11])[CH:3]=1.[CH3:12][S:13][C:14]1[CH:15]=[C:16]([CH:18]=[CH:19][CH:20]=1)[NH2:17]>>[CH3:12][S:13][C:14]1[CH:15]=[C:16]([NH:17][C:6](=[O:8])[C:5]2[CH:9]=[CH:10][C:2]([Br:1])=[CH:3][C:4]=2[F:11])[CH:18]=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 15693Benzenamine, 3-(methylthio)-HCID 3026814-Bromo-2-fluorobenzoic acid

Product 1

HCID 9072559HCID 9072559, compound

Procedure

460 mg of N1-[3-(methylsulfanyl)phenyl]-4-bromo-2-fluorobenzamide obtained in the same manner as in Production Example 32 from 4-bromo-2-fluorobenzoic acid and 3-(methylthio)aniline was stirred for 1.5 hours together with 1.23 g oxone in 15 mL tetrahydrofuran, 10 mL methanol and 10 mL water. The reaction solution was extracted with ethylacetate and purified by NH silica gel column to give 500 mg of the title compound.

Sources & evidence

ORD record
ord-de9f6a334b8946788a458cefe95465ad
Source dataset
uspto-grants-2006_07
Patent number
US07074801B1

Reaction notes

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