反应详情

10 mL solution of 432 mg 2-fluoro-5-methylsulfonylphenylamine (compound in Production Example 338) and 490 mg bis(2-chloroethyl)amine hydrochloride in 1,2-dichlorobenzene was stirred at 200° C. for 9 hours. The reaction mixture was neutralized by adding an aqueous saturated sodium bicarbonate solution and then extracted with dichloromethane. The organic layer was dried over anhydrous sodium sulfate, the solvent was removed, and the resulting crude product was purified by NH silica gel column chromatography (ethyl acetate/hexane) to give 230 mg of the title compound (dark brown solid).

1. extractionextracted with dichloromethane
2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
3. customthe solvent was removed
4. customthe resulting crude product was purified by NH silica gel column chromatography (ethyl acetate/hexane)