Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | Binap, (A+-)- | HCID 634876 | — |
| Reactant | 5-Bromo-2-fluorobenzonitrile | HCID 2724900 | — |
| Catalyst | Tris(dibenzylideneacetone) dipalladium | HCID 9832798 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 22032003 | HCID 22032003 | — |
Reaction Steps
1.24 g of 2,2′-bis (diphenylphosphino)-1,1′-binaphthyl and 229 mg of tris (dibenzylideneacetone) dipalladium were dissolved in toluene and stirred at 80° C. for 10 minutes. The reaction mixture was returned to room temperature, and 2.28 g cesium carbonate, 1.0 g 5-bromo-2-fluorobenzonitrile and 1.09 g t-butyl 1-piperazine carboxylate were added thereto and stirred at 80° C. for 12 hours. The reaction solution was purified by silica gel column chromatography to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07074801B1 |
|---|
| Source dataset | uspto-grants-2006_07 |
|---|
| ORD ID | ord-a7dcc9b3fced469691d85657b923039b |
|---|
| Source note | uspto-grants-2006_07 |
|---|
