Triethylamine → HCID 23537499, compound

Participants

Reaction Steps

0.2 g 4-(6-chloroquinazolin-4-yl)-2-fluorobenzoic acid (compound in Production Example 386), 41 mg cyclopropylamine and 0.12 mL triethylamine were dissolved in 6 mL dichloromethane, then 320 mg benzotriazol-1-yloxytris(dimethylamino)-phosphonium hexafluorophosphate was added thereto, and the mixture was stirred at room temperature for 3 hours. The reaction solution was purified by NH silica gel column chromatography (hexane/ethyl acetate) and then recrystallized from methanol/ethyl acetate/ether, to give 162 mg of the title compound as colorless crystals.

Provenance & Evidence