HCID 22032377, compound → HCID 22031666, compound

Participants

Reaction Steps

1.41 g of t-butyl 4-[hydroxy-(5-methylsulfanylthiophen-2-yl)-methyl]-piperidine-1-carboxylate (compound in Production Example 389) was dissolved in 40 mL acetone, and 14 g manganese dioxide was added thereto and stirred at room temperature for 24 hours. The reaction mixture was filtered through Celite, then the solvent was removed to give 1.14 g t-butyl 4-(5-methylsulfanylthiophen-2-carbonyl)piperidine-1-carboxylate, 5 mL of 4 N hydrogen chloride in ethyl acetate was added thereto, and the mixture was left for 1 hour. The solvent was removed, and the precipitated crystals were washed with ethyl acetate/ether, to give 0.75 g of the title compound as colorless crystals.

Provenance & Evidence