Hydrazine hydrate (1:1) → 6-Bromo-4-quinazolinecarboxylic acid hydrazide

Participants

Reaction Steps

A mixture of 961 mg methyl 6-bromoquinazoline-4-carboxylate (compound in Production Example 413), 0.9 mL hydrazine monohydrate and 70 mL methanol was stirred at room temperature for 30 minutes, and the precipitated crystals were collected by filtration. The filtrate was evaporated to give additional crystals. The title compound, 838 mg in total, was obtained as pale yellow crystals.

Provenance & Evidence