Ammonium Chloride → HCID 22031350, compound

Participants

Reaction Steps

125 mg benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate, 1-hydroxy-1H-benzotriazole monohydrate, 83 mg diisopropylethylamine, and 18 mg ammonium chloride were added in this order to a mixture of 100 mg 4-{4-[3-(2-pyridyl)imidazo[1,2-a]pyridin-6-yl]-1-trityl-1H-3-pyrazolyl} benzoic acid obtained in Example 46 and 3 mL N,N-dimethylformamide, and the mixture was stirred at room temperature for 2 hour. Ethyl acetate and water were added to the reaction solution, the organic layer was separated, the solvent was evaporated, and the residue was purified by NH silica gel column chromatography (hexane/ethyl acetate) to give 114 mg of the title compound as a colorless amorphous.

Provenance & Evidence