4-Methylmorpholine → HCID 22031972, compound

Participants

Reaction Steps

17 mg N-methyl morpholine and 13 mg 1-hydroxy-1H-benzotriazole monohydrate were added in this order at room temperature to a mixture of 50 mg 4-{4-[3-(2-pyridyl)imidazo[1,2-a]pyridin-6-yl]-1-trityl-1H-3-pyrazolyl} benzoic acid obtained in Example 46, 7.7 mg morpholine, 17 mg 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride and 8 mL N,N-dimethylformamide. Ethyl acetate and water were added to the reaction solution, and the organic layer was separated, washed twice with water and then with brine and dried over anhydrous sodium sulfate. The drying agent was filtered off, the filtrate was evaporated, and the residue was purified by NH silica gel column chromatography (hexane/ethyl acetate) to give 52 mg of the title compound as a colorless amorphous.

Provenance & Evidence