Methanesulfonyl chloride → HCID 22032413, compound

HRID 1792524Notes

Reaction equation

HRID 1792524 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[N:11]2[CH:12]=[C:13]([C:16]3[C:17]([C:40]4[CH:46]=[CH:45][C:43]([NH2:44])=[CH:42][CH:41]=4)=[N:18][N:19]([C:21]([C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH:20]=3)[CH:14]=[CH:15][C:10]2=[N:9][CH:8]=1.[CH3:47][S:48](Cl)(=[O:50])=[O:49]>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[N:11]2[CH:12]=[C:13]([C:16]3[C:17]([C:40]4[CH:46]=[CH:45][C:43]([NH:44][S:48]([CH3:47])(=[O:50])=[O:49])=[CH:42][CH:41]=4)=[N:18][N:19]([C:21]([C:34]4[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=4)([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH:20]=3)[CH:14]=[CH:15][C:10]2=[N:9][CH:8]=1

Participants

3

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 22031645HCID 22031645, compound

Product 1

HCID 22032413HCID 22032413, compound

Procedure

26 mg 4-{4-[3-(2-pyridyl)imidazo[1,2-a]pyridin-6-yl]-1-trityl-1H-3-pyrazolyl}aniline obtained in Example 49 and 9 μL methyl sulfonyl chloride were reacted in the same manner as in Example 20, to give 14 mg of the title compound as a colorless amorphous.

Sources & evidence

ORD record
ord-de203dd9b1d74014a54716b53a9de7c2
Source dataset
uspto-grants-2006_07
Patent number
US07074801B1

Reaction notes

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