Dichloromethane → HCID 178504998, compound

Participants

Reaction Steps

A mixture of 71 mg N-(4-{6-[3-(4-fluorophenyl)-1-trityl-1H-4-pyrazolyl]imidazo[1,2-a]pyridin-3-yl}phenyl)-methane sulfonamide obtained in Example 20, 0.36 mL trifluoroacetic acid and 5 mL dichloromethane was stirred overnight at room temperature. The reaction solution was cooled and made weakly alkaline with 5 N aqueous sodium hydroxide, followed by adding ethyl acetate and water to separate an organic layer. The organic layer was washed with brine and dried over anhydrous sodium sulfate. The drying agent was filtered off, the filtrate was evaporated, the residue was triturated with diethyl ether, and the crystals were separated by filtration. This product was dried under vacuum to give 33 mg of the title compound as a white solid.

Provenance & Evidence