Tributyltin Chloride → 5-{6-[3-(4-Fluorophenyl)-1-trityl-1H-4-pyrazolyl]imidazo-[1,2-a]pyridin-3-yl}-2-thiophene carboxamide

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A mixture of 200 mg 6-[3-(4-fluorophenyl)-1-trityl-1H-4-pyrazolyl]-3-(1,1,1-tributylstannyl)imidazo[1,2-a]-pyridine prepared from 6-[3-(4-fluorophenyl)-1-trityl-1H-4-pyrazolyl]-3-iodoimidazo[1,2-a]pyridine (compound in Production Example 39) and tributyltin chloride by the same method as in Production Example 48, 51 mg 5-bromo-2-thiophene carboxamide, 14 mg tetrakis (triphenylphosphine)palladium and 3 mL xylene was stirred at 120° C. for 2 hours under nitrogen atmosphere. The solvent was evaporated, and the residue was purified by silica gel chromatography (ethyl acetate/methanol) to give 37 mg of the title compound as a colorless amorphous.

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