Hydrogen chloride-ethyl acetate → HCID 178478872, compound

HRID 1792537Notes

Reaction equation

HRID 1792537 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]3[CH:13]=[C:14]([C:17]4[C:18]([C:22]5[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=5)=[N:19][NH:20][CH:21]=4)[CH:15]=[CH:16][C:11]=3[N:10]=[C:9]2[O:29]C)=[CH:4][CH:3]=1.[ClH:31].C(OCC)(=O)C>CO>[ClH:31].[ClH:31].[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]3[CH:13]=[C:14]([C:17]4[C:18]([C:22]5[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=5)=[N:19][NH:20][CH:21]=4)[CH:15]=[CH:16][C:11]=3[N:10]=[C:9]2[OH:29])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 178493955HCID 178493955, compound

Product 1

HCID 178478872HCID 178478872, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

15 mg 1-(4-fluorophenyl)-6-[3-(4-fluorophenyl)-1H-4-pyrazolyl]-2-methoxy-1H-benzo [d] imidazole obtained in Example 139 was dissolved in methanol, then 2 mL of 4 N hydrochloric acid/ethyl acetate was added thereto, and the solvent was evaporated. The residue was crystallized from methanol/ether and then washed with ethyl acetate to give 12 mg of the title compound as colorless crystals.

Workup

  1. customthe solvent was evaporated
  2. customThe residue was crystallized from methanol/ether
  3. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-f2facef0fc7d47cfa2f2bb2ba67f9cbb
Source dataset
uspto-grants-2006_07
Patent number
US07074801B1

Reaction notes

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