Sodium Thiosulfate → HCID 22032351, compound

Participants

Reaction Steps

1 mL aqueous solution of 86 mg oxone was added at room temperature to a solution of 67 mg 4-[5-(methylsulfanyl)-2-thienyl]-6-(3-methyl-1-trityl-1H-4-pyrazolyl)quinoline obtained in Example 155 in tetrahydrofuran, and the mixture was stirred for 1 hour. Further, 60 mg oxone was added thereto and stirred overnight. An aqueous saturated sodium thiosulfate solution was added to the reaction solution, and the mixture was stirred. Then, ethyl acetate, an aqueous saturated sodium bicarbonate solution and water were added thereto, and the organic layer was separated, washed with brine and dried over anhydrous sodium sulfate. The drying agent was filtered off, the filtrate was evaporated, and the residue was purified by silica gel column chromatography (hexane/ethyl acetate), to give 35 mg of the title compound as a pale yellow amorphous.

Provenance & Evidence