1-Pyrrolidinecarbonyl chloride → HCID 23537805, compound

HRID 1792553Notes

Reaction equation

HRID 1792553 reaction equation
[N:1]1([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:17]4[C:18]([C:41]([F:44])([F:43])[F:42])=[N:19][N:20]([C:22]([C:35]5[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=5)([C:29]5[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=5)[C:23]5[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=5)[CH:21]=4)[CH:15]=3)[N:10]=[CH:9][CH:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[N:45]1([C:50](Cl)=[O:51])[CH2:49][CH2:48][CH2:47][CH2:46]1>>[N:45]1([C:50]([N:4]2[CH2:5][CH2:6][N:1]([C:7]3[C:16]4[C:11](=[CH:12][CH:13]=[C:14]([C:17]5[C:18]([C:41]([F:43])([F:42])[F:44])=[N:19][N:20]([C:22]([C:23]6[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=6)([C:35]6[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=6)[C:29]6[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=6)[CH:21]=5)[CH:15]=4)[N:10]=[CH:9][CH:8]=3)[CH2:2][CH2:3]2)=[O:51])[CH2:49][CH2:48][CH2:47][CH2:46]1

Participants

3

Reactant 2

HCID 709371-Pyrrolidinecarbonyl chlorideHCID 22031274HCID 22031274, compound

Product 1

HCID 23537805HCID 23537805, compound

Procedure

118 mg 4-piperazin-1-yl-6-(3-trifluoromethyl-1-trityl-1H-4-pyrazolyl)quinoline obtained in Example 188 and 33 μL 1-pyrrolidine carbonyl chloride were reacted in the same manner as in Example 193, to give 126 mg of the title compound as a colorless amorphous.

Sources & evidence

ORD record
ord-668dc14ba70349838cac034d9938ccbf
Source dataset
uspto-grants-2006_07
Patent number
US07074801B1

Reaction notes

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