2-chloro-N,N-dimethylacetamide → HCID 22031369, compound

HRID 1792579Notes

Reaction equation

HRID 1792579 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[N:11]2[CH:12]=[C:13]([C:16]3[C:17]([C:40]4[CH:45]=[CH:44][C:43]([OH:46])=[CH:42][CH:41]=4)=[N:18][N:19]([C:21]([C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH:20]=3)[CH:14]=[CH:15][C:10]2=[N:9][CH:8]=1.Cl[CH2:48][C:49]([N:51]([CH3:53])[CH3:52])=[O:50]>>[CH3:52][N:51]([CH3:53])[C:49](=[O:50])[CH2:48][O:46][C:43]1[CH:42]=[CH:41][C:40]([C:17]2[C:16]([C:13]3[CH:14]=[CH:15][C:10]4[N:11]([C:7]([C:2]5[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=5)=[CH:8][N:9]=4)[CH:12]=3)=[CH:20][N:19]([C:21]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)([C:34]3[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=3)[C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[N:18]=2)=[CH:45][CH:44]=1

Participants

3

Reactant 2

HCID 758862-chloro-N,N-dimethylacetamideHCID 135763129HCID 135763129, compound

Product 1

HCID 22031369HCID 22031369, compoundYield 77.8%

Procedure

90 mg 4-{4-[3-(pyridin-2-yl)imidazo[1,2-a]pyridin-6-yl]-1-trityl-1H-pyrazol-3-yl}phenol (compound in Example 353) and 28 mg 2-chloro-N,N-dimethylacetamide were reacted under the same conditions as in Example 190, to give 80 mg of the title compound as a pale yellow amorphous matter.

Sources & evidence

ORD record
ord-733d40a2b793406098e5007d03145a8b
Source dataset
uspto-grants-2006_07
Patent number
US07074801B1

Reaction notes

Loading…